Macrophages accumulate free cholesterol in advanced atherosclerotic lesions, resulting in macrophage apoptosis and progression of lesions 1,2,3,4,5,6,7,8. Previous studies with cultured macrophages ...
When newly synthesized proteins translocate into the endoplasmic reticulum (ER) lumen, they undergo 'quality control'. An elaborate system of chaperones helps proteins to fold and prevents misfolded ...
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