A genome-wide CRISPR study maps 331 genes essential for early brain development, identifying PEDS1 as a new ...

For decades, geneticists have known that most common illnesses are not caused by a single rogue gene but by intricate constellations of DNA variants acting together in specific cells. Now a new ...

A sweeping genetic screen reveals how the brain is built and exposes a hidden gene behind a newly discovered childhood brain ...

Researchers have conducted the most comprehensive analysis to date linking plasma proteins to genetic variation in ...

MPN-BP transformation is driven by sequential mutations disrupting genomic stability, with TP53 mutations being strong predictors of progression. TP53 mutations confer a selective growth advantage, ...

The Collaborative Cross (CC) mouse resource has emerged as an indispensable platform for elucidating the genetic basis of complex traits. By combining high levels of genetic diversity from eight ...

The contribution of genetics to the variability in people’s metabolism has remained largely unknown. This is, in part, because genetic studies of human metabolism have been limited in scale and ...

The pathology of mental disorders is complex. Researchers can’t just attribute mental disorders to one or a few single mutations in a gene or protein — there are too many factors at play. After all, ...

The genetics of autism has long been one of the most intricate puzzles in neurodevelopmental science. Today, the pieces are coming together more rapidly than ever before. Landmark projects such as the ...

Genetics discoveries are rapidly identifying the people at greater risk for cancers and other diseases, but researchers at HealthPartners are concerned that they are happening too fast for doctors and ...