Where: Lucas Oil Stadium | Indianapolis, IN When: December 22, 2025, 8:15 p.m. We’ve got one game left for Week 16 of the 2025/’26 NFL season. This week’s Monday Night Football features the San ...

The San Francisco 49ers hit the road in Week 16 for a primetime, interconference battle with the Indianapolis Colts at Lucas Oil Stadium on Monday night, and Kyle Shanahan's squad earned a 48-27 ...

The Indianapolis Colts lose to the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football': Score updates, ...

In the final game of what has been a wild Week 16, the Indianapolis Colts host the San Francisco 49ers on "Monday Night ...

Brock Purdy threw a career-high five touchdown passes and Dee Winters returned an interception 74 yards for a score to lead the San Francisco 49ers to a 48-27 victory at Indianapolis.

Another year, another collapse, another humiliating loss in prime time for the Indianapolis Colts. The Colts dropped their fifth-straight game as they fell to the San Francisco 49ers 48-27 on Monday ...

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats ...