Deep inside the brain is a small but powerful region called the substantia nigra. Its job is to produce dopamine, a messenger molecule that allows your body to move smoothly and with control. But these dopamine-producing cells are vulnerable. Over time, they can be damaged by inflammation, toxins such as heavy metals, or even certain infections. In some cases, the immune system may mistakenly contribute to this damage. As these cells decline, dopamine levels drop—and the ability to move easily b

Today's mini been is here! Pathophysiology of Parkinson's Disease Parkinson's is a progressive, neurodegenerative disorder of the melanin-containing-dopaminergic neurons in the anterior part of the substantia nigra pars compacta. In this video, Dr. Mobeen Syed discusses the pathophysiology of Parkinson's disease. Nerve fibers from the cell body of neurons in the substantia nigra go to the neostriatum giving the nigrostriatal pathway of nerve impulses. It is a dopaminergic pathway that releases G